What is a Biostimulator?

• A Biostimulator, also known as a Collagen Biostimulator, is a substance that stimulates the body to naturally produce collagen.
• When injected into the skin, it helps replenish collagen that has diminished with age, resulting in firmer, plumper, more elastic skin with improved overall health and strength.

Benefits of Biostimulators

• Stimulates collagen production, strengthening the skin’s structure
• Reduces wrinkles and sagging by enhancing skin elasticity
• Provides natural and long-lasting results since it promotes the body’s own collagen production
• Improves skin texture and hydration, giving a healthier appearance

Popular Types of Biostimulators

1. Sculptra (Poly-L-Lactic Acid - PLLA)

• Stimulates long-term collagen production
• Commonly used for cheeks, temples, and jawline

2. Radiesse (Calcium Hydroxylapatite - CaHA)

• Provides immediate volume and collagen stimulation
• Helps lift and firm the skin with long-lasting effects

How is it different from fillers?

• Fillers (Hyaluronic Acid - HA) provide instant volume but gradually dissolve over time.
• Biostimulators do not give immediate results but instead encourage the body to produce its own collagen, leading to firmer, healthier skin in the long run.

Biostimulators are an excellent option for those looking to restore skin quality from within without relying solely on direct fillers.

Biostimulators, such as Poly-L-Lactic Acid (PLLA), function by stimulating the body’s natural collagen production. When injected into the skin, PLLA particles act as a scaffold, promoting fibroblast activity, which leads to the synthesis of new collagen fibers. Over time, this process enhances skin firmness, elasticity, and overall structure, effectively counteracting the signs of aging.  Upon injection, PLLA particles are recognized by the body’s immune system, initiating a mild inflammatory response.  This response attracts macrophages and fibroblasts to the injection site, where fibroblasts begin producing collagen around the PLLA particles.  As the PLLA gradually degrades into lactic acid, the newly formed collagen fibers replace the space previously occupied by the particles, resulting in increased dermal volume and improved skin texture.  It’s important to note that the effects of biostimulators develop gradually, with visible improvements typically emerging over several weeks to months as collagen production increases.  The longevity of results can vary depending on individual factors and the specific product used. 

How Many Brands of Biostimulators Are There?

Currently, there are several brands of Biostimulators available, but the two most popular ones worldwide—approved by the FDA in Thailand, the U.S., and South Korea—and known for their high collagen-stimulating effects are: 

1. Sculptra

• Sculptra contains PLLA (Poly-L-Lactic Acid), a compound that stimulates new collagen production. 
• It helps restore the skin’s structure from within, making sagging skin appear firmer and giving the face a naturally youthful look. 

2. Radiesse

• Radiesse is an injectable collagen stimulator made of CaHA (Calcium Hydroxylapatite). 
• It stimulates collagen production beneath the skin, providing results similar to dermal fillers. 
• It enhances skin elasticity, firmness, and facial contour definition. 

Sculptra vs. Radiesse: A Collagen Stimulation Comparison

Both Sculptra and Radiesse are leading Biostimulators that are safe and FDA-approved, effectively stimulating collagen production and slowing down aging.  However, they differ in composition and mechanism: 

• Sculptra (PLLA) works by causing a mild inflammatory response at the cellular level, which activates white blood cells. [cite: 20] This process signals fibroblast cells to produce new collagen and elastin over time. 
• Radiesse (CaHA) mimics the natural composition of human bones, directly stimulating fibroblast cells to increase collagen production.

Additionally, they differ in longevity: 

• Sculptra results can last over 24 months.
• Radiesse lasts about 12–15 months.

Both options are excellent for collagen regeneration and skin rejuvenation, but the choice depends on individual needs and treatment goals.

Comparison of Different Types of Biostimulators

Aside from the previously mentioned options, there are several other types of Biostimulators, each differing in composition, properties, and skin benefits.

1. Aesthefil

• Key Ingredients: PDLLA (Poly-d,l-lactic acid) and Carboxymethyl Cellulose (CMC)
• Properties:
  • Easily dissolves in water, making it easy to inject
  • Stimulates collagen production to a lesser extent
  • Helps improve skin firmness and smoothness

2. Lenisna

• Key Ingredients: PDLLA (Poly-d,l-lactic acid) and Hyaluronic Acid (HA)
• Properties:
  • Water-soluble and easy to inject
  • Limited collagen stimulation
  • HA helps plump the skin and retain moisture

3. Juvelook

• Key Ingredients: PDLLA (Poly-d,l-lactic acid) and Hyaluronic Acid (HA)
• Properties:
  • Water-soluble and easy to inject
  • Minimal collagen stimulation
  • Contains the lowest concentration of PDLLA, making it ideal for delicate areas like under the eyes

4. Sculptra

• Key Ingredients: PLLA (Poly-L-lactic acid)
• Properties:
  • Long-lasting collagen stimulation
  • Requires precise injection techniques for best results

Each Biostimulator has unique properties that make it suitable for different skin concerns and areas of the face.  The right choice depends on individual skin needs and treatment goals. 

Who Is Biostimulator Suitable For?

Injecting Biostimulators stimulates natural collagen production beneath the skin, providing long-term results. It is particularly beneficial for individuals with the following skin concerns: 

• Sagging skin and loss of firmness due to aging 
• Wrinkles and fine lines that make the face appear older 
• Skin deterioration—recommended for individuals aged 25 and above who want to prevent premature aging 
• Those seeking long-lasting results, as Biostimulators can last up to 2 years 

Who Should Avoid Biostimulators?

While collagen biostimulators are effective, they may not be suitable for everyone.  If you are considering the treatment, consult a doctor, especially if you fall into the following categories: 

• Individuals taking certain medications, such as NSAIDs, immunosuppressants, or corticosteroids for extended periods 
• Those with mental health conditions 
• People with neurological disorders affecting sensory perception, diabetes, autoimmune diseases, herpes, or epilepsy
• Anyone with a history of severe allergic reactions, including anesthesia allergies 
• Individuals with active skin inflammation in the treatment area 
• Pregnant or breastfeeding women 
• Those with blood clotting disorders or individuals taking blood thinners (e.g., anticoagulants), as they may experience bruising, hematomas, or excessive bleeding 
• Impatient individuals who expect immediate results—since collagen biostimulators rely on the body’s natural collagen production, visible improvement takes some time 

Before proceeding with Biostimulator injections, it is crucial to consult a medical professional to ensure the treatment is safe and appropriate for your condition.

Injecting Biostimulators offers several advantages that enhance skin health and appearance: 

• Stimulates Collagen Production: Encourages the body to produce collagen, improving skin firmness and elasticity.
• Reduces Wrinkles and Fine Lines: By increasing collagen levels, it helps diminish the appearance of wrinkles and fine lines. 
• Enhances Skin Elasticity: Promotes the production of elastin fibers, leading to more supple and resilient skin. 
• Improves Skin Hydration: Stimulates proteoglycan activity, which helps the skin retain moisture, resulting in a hydrated and plump appearance. 
• Promotes Healthy Blood Circulation: Encourages angiogenesis, the formation of new blood vessels, ensuring better nutrient delivery to the skin and a healthy, radiant complexion. 

These benefits make Biostimulators a valuable option for those looking to rejuvenate their skin naturally and effectively.

Limitations of Biostimulator Injections

While Biostimulators offer numerous skin benefits, there are some limitations to consider before undergoing this collagen-stimulating treatment: 

• Not suitable for individuals allergic to Biostimulator components such as Poly-L-lactic acid (PLLA), Carboxymethylcellulose (CMC), or Non-pyrogenic mannitol 
• Not recommended for individuals with autoimmune diseases (e.g., SLE) or those taking immunosuppressant medications 
• Not suitable for individuals with a history of severe allergic reactions to Biostimulators 
• Avoid in cases of prior injections leading to skin inflammation or infections 

How Long Does Biostimulator Last?

• Visible changes begin to appear within 1-2 months after injection 
• A single treatment lasts only 2-4 months 
• For optimal and long-lasting results, 2-3 sessions are recommended in the initial phase 
• With proper maintenance, results can last up to 2 years 

Pre-Treatment Preparation

To ensure safety and effectiveness, follow these preparation guidelines:

• Avoid other facial procedures 2-4 weeks before the injection 
• Refrain from smoking and alcohol consumption at least 1-3 days prior 
• Discontinue blood-thinning medications and vitamins at least 1 week before to prevent excessive bruising 
• Get enough rest and maintain a balanced diet to support collagen production 

Post-Treatment Care

Proper aftercare is essential for the best results: 

• Avoid cosmetics and skincare products for at least 12 hours after injection
• Gently massage any lumps under the skin
• Apply a cold compress to reduce swelling or bruising if needed 
• Attend follow-up appointments for treatment evaluation 

By following these pre- and post-care instructions, you can maximize the benefits of Biostimulator injections and maintain healthy, youthful skin for longer.